Sylvestre Bonnet, Dr.

  • associate professor
Research theme:

Telephone number
+31 (0)71 527 4260
E-mail address
Faculty of Science, Leiden Institute of Chemistry, Metals in Catalysis, Biomimetics & Inorganic Materials
Office address
Gorlaeus Laboratories
Einsteinweg 55
2333 CC Leiden
roomnumber EE.3.09


SB did his PhD on molecular machines in the group of Jean-Pierre Sauvage in Strasbourg, France, where he graduated in 2005. He then moved to The Netherlands as a postdoctoral fellow, first in the catalysis group of Gerard van Koten (Utrecht), then with Jan Reedijk (Leiden) where he worked on spin crossover. After obtaining a Veni grant in 2008 in the Chemical Biology group of Bert Klein Gebbink and Antoinette Killian (Utrecht) he moved to Leiden in 2009 where he completed a Tenure Track in Inorganic Chemistry. He obtained a Vidi grant in 2012 and an ERC Starting Grant in 2013, and became Associate Professor in Leiden in 2015. His expertise lies at the crossing point between inorganic chemistry, photochemistry, and liposomes. His current research interests are light-activated anticancer metallorugs, photocatalysis, and coordination chemistry at lipid bilayers.

Key publications

  1. Green light-induced apoptosis in cancer cells by a tetrapyridyl ruthenium prodrug offering two trans coordination sites
    V. H. S. van Rixel, B. Siewert, S. Hopkins, S. H. C. Askes, A. Busemann, M. A. Siegler, S. Bonnet*, Chem. Sci. 2016, 7, 4922-4929
  2. Chemical Swarming: Depending on Concentration, an Amphiphilic Ruthenium Polypyridyl Complex Induces Cell Death via two different Mechanisms
    B. Siewert, V. H. S. van Rixel, E. J. van Rooden, S. L. H. Higgins, M. van der Stelt, S. Bonnet*, Chem. Eur. J. 2016, 22, 10960-10968
  3. Rate and stability of photocatalytic water oxidation using [Ru(bpy)3]2+ as photosensitizer”, B. Limburg, E. Bouwman, S. Bonnet*, ACS Catalysis 2016, DOI: 10.1021/acscatal.6b00107
  4. In vitro cell irradiation protocol for testing photopharmaceuticals and the effect of blue, green, and red light on human cancer cell lines
    S. L. Hopkins, B. Siewert, S. Askes, P. Veldhuizen, R. Zwier, M. Heger, S. Bonnet*, Photochem. Photobiol. Sci. 2016, 15, 644 - 653
  5. "Activation of a Photodissociative Ruthenium Complex by Triplet–Triplet Annihilation Upconversion in Liposomes
    S. H. C. Askes, A. Bahreman, S. Bonnet*, Angew. Chem. Int. Ed. 2014, 53, 1029-1033
  6. "Ruthenium Polypyridyl Complexes Hopping at Anionic Lipid Bilayers through a Supramolecular Bond Sensitive to Visible Light"
    A. Bahreman, B. Limburg, M. A. Siegler, R. Koning, A. J. Koster, S. Bonnet, Chem. Eur. J. 2012, 18, 10271 – 10280
  7. Ruthenium-Decorated Lipid Vesicles: Light-Induced Release of [Ru(terpy)(bpy)(OH2)]2+, and Thermal Back Coordination
    S. Bonnet*, B. Limburg, J. Meeldijk, R. J. M. Klein Gebbink, J. A. Killian, J. Am. Chem. Soc. 2011, 133, 252-261
  8. N-Acetylmethionine and Biotin as Photocleavable Protective Groups for Ruthenium Polypyridyl Complexes
    R. E. Goldbach, I. Rodriguez-Garcia, J. H. van Lenthe, M. A. Siegler, S. Bonnet*, Chem. Eur. J. 2011, 17, 9924-9929.
  9. A two-step spin-crossover mononuclear iron(II) complex with a [HS-LS-LS] intermediate phase
    S. Bonnet, M. A. Siegler, J. Sánchez Costa, G. Molnár, A. Bousseksou, A. L. Spek, P. Gamez, J. Reedijk, Chem. Commun. 2008, 5619-5621.
  10. "Transition-metal-complexed molecular machine prototypes"
    S. Bonnet, J.-P. Collin, M. Koizumi, P. Mobian, J.-P. Sauvage*, Adv. Mat. 2006, 18, 1239-1250.